Thalassemia
Thalassemia — also called Mediterranean anemia — is an inherited blood disorder characterized by less hemoglobin and fewer red blood cells in your body than normal. Defects in the genes that make hemoglobin cause thalassemia. Hemoglobin is the substance in red blood cells that allows the cells to carry oxygen from your lungs to the other parts of your body. Because of low hemoglobin and a low amount of red blood cells, thalassemia results in anemia.
Main Causes Of Thalassemia
Alpha Cause Thalassemia
People whose hemoglobin does not produce enough alpha protein have alpha thalassemia. It is commonly found in Africa, the Middle East, India, Southeast Asia, southern China, and occasionally the Mediterranean region.
Beta Causes Thalassemia
People whose hemoglobin does not produce enough beta protein have beta thalassemia. It is found in people of Mediterranean descent, such as Italians and Greeks, and is also found in the Arabian Peninsula, Iran, Africa, Southeast Asia and southern China.
Delta Causes thalassemia
As well as alpha and beta chains being present in hemoglobin about 3% of adult hemoglobin is made of alpha and delta chains. Just as with beta thalassemia, mutations can occur which affect the ability of this gene to produce delta chains. A mutation that prevents formation of any delta chains is termed a delta0 mutation, whereas one that decreases but does not eliminate production of delta chain is termed a delta mutation.
Treatments And Tests Of Thalassemia
People with severe thalassemia receive regular blood transfusions and folate supplements. People who receive the blood transfusions should avoid iron supplements and oxidative drugs such as sulfonamides, because iron levels in their bodies can become toxic.
Prenatal testing can be done around the 11th week of pregnancy using chorionic villi sampling (CVS). This involves removing a tiny piece of the placenta. Or, the fetus can be tested with amniocentesis around the 16th week of pregnancy. In this procedure, a needle is used to take a sample of the fluid surrounding the baby for testing.
We used the algorithm SVM (support vector machine) to find a reliable formula that can separate patients with Iron deficiency anemia/ healthy from patients with ß thalassemia minor (carriers). This formula can be inserted to any automatic blood counter and search for suspected carriers without deliberately intention and without any further blood test
Tags: main causes of thalassemia thalassemia treatments and tests Of thalassemia
Related Posts
Fatal error: Call to undefined function: wp23_related_posts() in /home/healthan/public_html/wp-content/themes/bloggingpro_wr/single.php on line 158